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The evidence combined BPC 157 with the time-dependently activated VEGFR2-Akt-eNOS signaling pathway, the increase in endothelial tube formation (chick chorioallantoic membrane (CAM)) (both suppressed by Dynasore, an endocytosis inhibitor), the increased expression and internalization of VEGFR2, and essential acceleration of blood flow recovery and vessel number to rescue hind limb ischemia in rats with a completely excised femoral artery [94]

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Pharmacokinetic Profile Route of Administration Subcutaneous Dosing Frequency Once daily Route of Administration : Subcutaneous injection Dosing Frequency : Once daily Half-Life : ~38 minutes in HIV+ patients 2 Formulation : Lyophilized acetate salt for reconstitution Formulation & Handling Reconstitute lyophilized powder in sterile bacteriostatic water for injection (0.9% benzyl alcohol) Store reconstituted solution at 2–8°C and use within 14 days Unreconstituted vials should be stored at −20°C in a dry, light-protected environment Avoid repeated freeze-thaw cycles